脊髓压迫和半横断损伤小鼠模型的时空基因表达谱及修复机制研究

徐波, 陈泰任, 方乾, 吴际

Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models

XU Bo, CHEN Tairen, FANG Qian, WU Ji

图2 假手术对照组、脊髓半横断损伤组和脊髓压迫损伤组小鼠宏观形态、恢复过程及运动功能的比较 注：A，CTR组、SCC组和HSCI组小鼠的脊髓体视镜明场图（白色虚线框内为脊髓造模状态）；B，SCC组和HSCI组小鼠在术后第1、3、7、14、21和28天恢复情况；C，为术后第28天SCC组（标记为a）和HSCI组（标记为b）小鼠恢复情况的对比图；D，脊髓损伤术后不同时间点的BBB评分。CTR，假手术对照组；SCC，脊髓压迫损伤组；HSCI；脊髓半横断损伤组。???与CTR组相比，P<0.001；#与组内前一个时间点相比，P<0.05。

Figure 2 Comparison of macroscopic morphology， recovery process and motor function of mice in sham-operated control group， spinal cord compression and hemisection spinal cord injury group Note： A， the spinal cord stereoscopy bright-field images of CTR group， SCC group and HSCI group， respectively（the white dashed box indicates the site of spinal cord modeling）； B， recovery of mice in SCC and HSCI groups at 1， 3， 7， 14， 21 and 28 days after modeling； C， the comparison chart of the recovery of mice in the SCC group （marked as a） and the HSCI group （marked as b） on the 28th day after surgery； D， BBB scores at different time points after SCI modeling. CTR， sham-operated control group； SCC， spinal cord compression injury group； HSCI， hemisection spinal cord injury group. ???P<0.001， compared with CTR group； #P<0.05， compared with the previous time point within the group.