脊髓压迫和半横断损伤小鼠模型的时空基因表达谱及修复机制研究

徐波, 陈泰任, 方乾, 吴际

Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models

XU Bo, CHEN Tairen, FANG Qian, WU Ji

图1 模型构建和实验过程的技术路线图 注：在术后第1、3、7、21和28天采用改良BBB（Basso-Beattie-Bresnahan）评分评估假手术对照（CTR）组，脊髓半横断损伤（HSCI）组和脊髓压迫损伤（SCC）组小鼠运动功能的恢复情况，并在术后第7和21天对三组小鼠脊髓损伤段组织进行RNA测序（RNA-seq）。

Figure 1 Technical roadmap for model construction and experimental process Note： On postoperative days 1， 3， 7， 21， and 28， the modified Basso-Beattie-Bresnahan scale was used to assess motor recovery in the sham-operated control （CTR） group， hemisection spinal cord injury （HSCI） group， and spinal cord compression injury （SCC） group. RNA-seq was performed on spinal cord tissue from the injured segments of mice in all three groups at days 7 and 21 post-surgery.