外泌体通过NRF2/SLC7A11/GPX4通路调控铁死亡治疗小鼠缺血性脑卒中

徐英韬, 王蒙蒙, 林平, 迟海涛, 王怡, 白鹰

Exosomes Treat Ischemic Stroke by Regulation of Ferroptosis Through the NRF2/SLC7A11/GPX4 Pathway in Mice

XU Yingtao, WANG Mengmeng, LIN Ping, CHI Haitao, WANG Yi, BAI Ying

图2 MCAO小鼠模型建立过程中MCA血流变化和脑梗死区TTC染色表现 注：A，黑色箭头所指为大脑中动脉（MCA），呈Y字型；B，短时间电凝（约2～3 s），血流开始减少；C，继续电凝（累计约5～6 s），血流基本中断；D，充分电凝（累计约8～10 s），血管完全闭塞；E，中动脉闭塞（MCAO）模型组脑切片的2，3，5-三苯基氯化四氮唑（TTC）染色结果，黑色箭头所指白色区域即为梗死区域。A～D图比例尺为3 mm；E图比例尺为5 mm。

Figure 2 MCA blood flow changes during MCAO model establishment and TTC staining of the cerebral infarction area Note： A， The black arrow indicates the middle cerebral artery （MCA）， which is Y-shaped； B， short-duration electrocoagulation （approximately 2-3 s）， during which blood flow begins to decrease；C， continued electrocoagulation （cumulative approximately 5-6 s）， with blood flow largely interrupted；D， sufficient electrocoagulation （cumulative approximately 8-10 s）， resulting in complete vascular occlusion； E， 2，3，5-triphenyltetrazolium chloride （TTC） staining results of brain sections in the middle cerebral artery occlusion （MCAO） model group， the white area indicated by the black arrow is the infarcted area. The scale bar in A-D indicates 3 mm； The scale bar in E indicates 5 mm.