美洲大蠊作为实验用动物模型的研究进展

周冠宇, 朱仕明, 刘方方

Research Advances on Periplaneta americana as an Experimental Animal Model

ZHOU Guanyu, ZHU Shiming, LIU Fangfang

图1 美洲大蠊生殖调控模式图 注：在咽侧体中，脑源神经肽allatostatin抑制JH合成，而IIS-TORC1信号促进JH合成；从咽侧体合成的JH分泌到血淋巴后，促进脂肪体的卵黄发生过程，进而生成Vg蛋白；Vg蛋白经运输到达卵母细胞并被其吸收，最终促进卵巢发育成熟。allatostatin，抑咽侧体神经肽；IIS，胰岛素/胰岛素样生长因子信号；TORC1，雷帕霉素靶蛋白复合物1；JH，保幼激素；vitellogenesis，卵黄发生；Vg，卵黄原蛋白。

Figure 1 Schematic diagram of reproductive regulation in P. americana Note： In corpora allata， brain-derived neuropeptide allatostatin inhibits JH biosynthesis， while IIS-TORC1 signaling promotes JH biosynthesis； The synthesized JH is secreted into the hemolymph， and it promotes the vitellogenesis process in the fat body， thereby generating Vg protein； The Vg protein is transported to oocytes and absorbed by them， ultimately promoting ovarian development and maturation. IIS， insulin/insulin-like growth factor signaling； TORC1， target of rapamycin complex 1； JH， juvenile hormone； Vg， vitellogenin.