药物安全评价用SD大鼠90 d喂养试验的背景数据研究
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秦超, 李双星, 赵婷婷, 蒋晨晨, 赵晶, 杨艳伟, 林志, 王三龙, 文海若
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Study on the 90-day Feeding Experimental Background Data of SD Rats for Drug Safety Evaluation
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QIN Chao, LI Shuangxing, ZHAO Tingting, JIANG Chenchen, ZHAO Jing, YANG Yanwei, LIN Zhi, WANG Sanlong, WEN Hairuo
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表1 SD大鼠血液学和凝血功能指标检查结果 (n=60， ±1.96 s)
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Table 1 Results of hematology and blood clotting indices in SD rats
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指标 Index | 雄性 Male | 雌性 Female |
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| WBC Ccell/(109·L-1) | 7.36±4.27 | 4.82±3.06 | | %Neut /% | 14.10±9.02 | 14.50±10.58 | | Neut Ccell/(109·L-1) | 1.04±1.04 | 0.67±0.53 | | %Lymph /% | 80.30±10.58 | 80.00±11.96 | | Lymph Ccell/(109·L-1) | 5.90±3.35 | 3.89±2.76 | | %Mono /% | 2.30±1.96 | 2.20±1.37 | | Mono Ccell/(109·L-1) | 0.17±0.20 | 0.10±0.08 | | %Eos /% | 1.50±0.98 | 1.70±1.37 | | Eos Ccell/(109·L-1) | 0.11±0.08 | 0.08±0.06 | | %Baso /% | 0.2±0.2 | 0.1±0.1 | | Baso Ccell/(109·L-1) | 0.01±0.01 | 0.01±0.01 | | RBC Ccell/(1012·L-1) | 8.90±0.74 | 8.05±0.69 | | HGB ρ/(g·L-1) | 155±14 | 148±10 | | HCT /% | 50.0±5.0 | 46.5±5.0 | | MCV /fL | 56.2±4.1 | 57.7±4.5 | | MCH m/(pg) | 17.4±1.4 | 18.4±1.2 | | MCHC ρ/(g·L-1) | 310±31 | 318±27 | | PLT Ccell/(109·L-1) | 996±321 | 939±300 | | MPV /fL | 8.2±3.7 | 8.3±2.9 | | %Retic /% | 3.24±5.94 | 2.40±1.43 | | Retic Ccell/(109·L-1) | 288.5±53.5 | 191.9±108.6 | | PT /s | 10.7±5.7 | 8.5±0.8 | | APTT /s | 16.9±5.5 | 12.8±3.9 |
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