生物3D打印研究及与临床前动物模型的交叉应用展望

胡敏, 董乐轩, 高怡, 奚子芪, 沈子皓, 唐瑞阳, 栾鑫, 汤忞, 张卫东

Prospects for 3D Bioprinting Research and Transdisciplinary Application to Preclinical Animal Models

HU Min, DONG Lexuan, GAO Yi, XI Ziqi, SHEN Zihao, TANG Ruiyang, LUAN Xin, TANG Min, ZHANG Weidong

图1 3种生物3D打印工艺类型的工作机制示意图 注：A，喷墨式生物3D打印（局部加热生物墨水，并膨胀一个气泡以推动液滴从喷嘴头喷出）；B，挤出式生物3D打印（逐层打印连续的细丝状生物墨水）；C，光固化生物3D打印［利用数字微镜装置（DMD）芯片，使得紫外光或其他光源模式化投射到生物墨水上］。

Figure 1 Schematic diagram of the working principles of three types of 3D bioprinting processes Note：A， Inkjet-based 3D bioprinting， in which localized heating of the bioink inflates an air bubble to push droplets out from the nozzle； B， Extrusion-based 3D bioprinting， which prints continuous filaments of bioink layer by layer； C， Light-based 3D bioprinting， which utilizes a digital micro-mirror device （DMD） chip to project patterned UV light or other light sources onto the bioink.