慢性肾脏病大鼠主动脉钙化模型的术式优化及效果评价

潘颐聪, 蒋汶洪, 胡明, 覃晓

Optimization of Surgical Procedure and Efficacy Evaluation of Aortic Calcification Model in Rats with Chronic Kidney Disease

PAN Yicong, JIANG Wenhong, HU Ming, QIN Xiao

图2 不同手术方式构建的慢性肾功能不全模型组大鼠的Kaplan-Meier生存曲线分析 注：横坐标表示切除两侧肾脏后第2天开始记录的时间（单位为天）。上图展示了接受不同方式手术的大鼠术后60 d累积生存率（Log-Rank检验，P=0.007 7），其中D组大鼠的存活率最高，与A、B、C组相比差异有统计学意义（P值分别为0.003 0、0.007 4、0.003 0），而且A、B、C组的大鼠均在术后10 d内大量死亡。

Figure 2 Kaplan-Meier survival curve analysis of rats in chronic renal insufficiency model groups constructed using different surgical methods Note： The horizontal axis represents the time （in days） recorded from the second day after the removal of both kidneys. Upper of the figure shows that there is a significant difference in the cumulative survival rate of rats after 60 days of surgery using different surgical methods （log-rank test， P=0.007 7）， The survival rate of rats in group D was the highest， with statistically significant differences compared to groups A， B， and C （P=0.003 0， P=0.007 4， P=0.003 0， respectively）. Moreover， rats in groups A， B， and C experienced high mortality within 10 days after surgery.