长春瑞滨诱导大鼠足背静脉炎模型的动态评价

姜萌, 郝淑兰, 仝立国, 仲启明, 高振飞, 王永辉, 王晞星, 吉海杰

Dynamic Evaluation of Vinorelbine-Induced Phlebitis of Dorsalis Pedis Vein in a Rat Model

JIANG Meng, HAO Shulan, TONG Liguo, ZHONG Qiming, GAO Zhenfei, WANG Yonghui, WANG Xixing, JI Haijie

图1 足背静脉炎模型大鼠不同时间点的患肢外观（A）和红外热成像（B）图 注：A，患肢外观；B，红外热成像（平均温度：>35.5 ℃且≤35.9 ℃呈绿色，>35.9 ℃且≤36.5 ℃呈蓝色，>36.5 ℃呈红色）。对照组大鼠于右后肢足背静脉注射0.1 mL生理盐水，模型组大鼠于右后肢足背静脉注射0.1 mL长春瑞滨溶液（4 mg/mL），连续观察9 d（Day 1、Day 3、Day 5、Day 7和Day 9分别指模型组第1、3、5、7和9天）。

Figure 1 Appearances （A） and infrared thermal images （B） of the injured limbs of phlebitis model rats at different time points Note： A， appearance of the injured hindlimb； B， infrared thermal imaging （average temperature： >35.5 ℃ and ≤35.9 ℃， green； >35.9 ℃ and ≤36.5 ℃， blue； >36.5 ℃， red）. The control group rats were injected with 0.1 mL of saline solution into the dorsal vein of the right hind limb， while the model group rats were injected with 0.1 mL of vinorelbine solution （4 mg/mL）. Observation continued for 9 consecutive days. Day 1， Day 3， Day 5， Day 7， and Day 9 refer to the first， third， fifth， seventh， and ninth day after modeling， respectively.