基于16S rRNA测序的2型糖尿病db/db小鼠模型口腔菌群差异分析

潘钱家, 葛峻沂, 胡楠, 华飞, 顾敏

Differential Analysis of Oral Microbiota in db/db Mouse Model of Type 2 Diabetes Utilizing 16S rRNA Sequencing

PAN Qianjia, GE Junyi, HU Nan, HUA Fei, GU Min

图4 db/db小鼠及db/m小鼠的口腔微生物菌群在属水平上的差异 注：A，db/db和db/m组唾液微生物群中50种优势物种的相对丰度热图；B～M，葡萄球菌属、鼠杆菌属、链球菌属、气球菌属、棒杆菌属、嗜冷咸海鲜球菌属、肠球菌属、变形杆菌属、副拟杆菌属、瘤胃球菌科下未分类属、肠杆菌属、假芽孢杆菌属水平的相对丰度。正态分布的数据由条形图表示，非正态分布的数据用箱线图表示。db/db小鼠为糖尿病实验组；db/m小鼠为正常对照组，每组8只。*P<0.05，**P<0.01，***P<0.001。

Figure 4 Differences in oral microbiota composition between db/db mice and db/m mice at the genus level Note： A， Heatmap showing the relative abundance of the top 50 dominant species in the saliva microbiota （db/db vs. db/m）； B-M， Relative abundance of the following genera： g_Staphylococcus， g_Muribacter， g_Streptococcus， g_Aerococcus， g_Corynebacterium， g_Jeotgalicoccus， g_Enterococcus， g_Proteus， g_Parabacteroides， g_Ruminococcaceae， g_Enterorhabdus， and g_Fictibacillus. Normally distributed data are presented as bar plots， and non-normally distributed data as box plots. Db/db mice served as the diabetic model， while db/m mice were the normal controls， n=8 per group. *P < 0.05， **P < 0.01， ***P < 0.001.