异常子宫出血大鼠模型的构建与评价
连辉, 姜艳玲, 刘佳, 张玉立, 谢伟, 薛晓鸥, 李健

Construction and Evaluation of a Rat Model of Abnormal Uterine Bleeding
LIAN Hui, JIANG Yanling, LIU Jia, ZHANG Yuli, XIE Wei, XUE Xiaoou, LI Jian
表1 异常子宫出血模型大鼠与正常对照大鼠子宫组织的差异表达基因中前10个上调和前10个下调基因的基本信息
Table 1 Basic information of the top 10 up-regulated and the top 10 down-regulated differentially expressed genes in uterine tissues between abnormal uterine bleeding model rats and normal control rats

编号

No.

基因符号

Gene symbol

log2差异倍数

log2(fold change)

q

q-value

功能概述

Summary

Up-regulated genes
1Scin4.1734.546×10-191Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. etc.
2Btc5.9617.347×10-158Enables epidermal growth factor receptor binding activity and growth factor activity. etc.
3Serpinb119.0211.630×10-142Predicted to enable serine-type endopeptidase inhibitor activity. etc.
4Slc16a126.2669.424×10-126Enables creatine transmembrane transporter activity. etc.
5Tprg18.3562.229×10-118Predicted to be active in cytoplasm. etc.
6Olfm48.1472.346×10-108Predicted to enable cadherin binding activity and structural molecule activity. etc.
7Tnfaip66.3443.099×10-93Predicted to enable several functions, including carboxylesterase activity. etc.
8Nck12.4511.127×10-84Predicted to enable several functions, including eukaryotic initiation factor eIF2 binding activity. etc.
9Actn41.1881.391×10-83Enables ubiquitin protein ligase binding activity. etc.
10Tmbim13.0271.062×10-82Predicted to enable calcium channel activity and death receptor binding activity. etc.
Down-regulated genes
1Gstm5-4.3933.077×10-61Enables glutathione transferase activity and identical protein binding activity. etc.
2Armh4-5.6714.422×10-54Predicted to enable TORC2 complex binding activity. etc.
3LOC102548820-7.0322.774×10-52-
4Arg2-4.3381.561×10-50Enables arginase activity and nitric-oxide synthase binding activity. etc.
5Frem2-6.4136.963×10-47Predicted to be involved in anatomical structure morphogenesis and cell adhesion. etc.
6Mppe1-1.3461.575×10-44Predicted to enable GPI anchor binding activity. etc.
7Lef1-3.8753.022×10-43Predicted to enable several functions, including DNA binding activity. etc.
8Smad9-4.0488.538×10-42Predicted to enable DNA-binding transcription factor activity, RNA polymerase Ⅱ-specific. etc.
9Miga1-1.9444.052×10-41Predicted to enable protein heterodimerization activity and protein homodimerization activity. etc.
10Bmpr1b-2.5151.387×10-38Predicted to enable several functions, including ATP binding activity. etc.