来曲唑缓释片皮下给药构建小鼠多囊卵巢综合征模型及其肝脏转录组学分析

许秋雨, 严国锋, 付丽, 范文华, 周晶, 朱莲, 仇淑雯, 张洁, 吴铃

A Mouse Model of Polycystic Ovary Syndrome Established Through Subcutaneous Administration of Letrozole Sustained-Release Pellets and Hepatic Transcriptome Analysis

XU Qiuyu, YAN Guofeng, FU Li, FAN Wenhua, ZHOU Jing, ZHU Lian, QIU Shuwen, ZHANG Jie, WU Ling

图 3 来曲唑和高脂饮食造模后小鼠差异表达基因的功能注释和富集分析 注：A，来曲唑造模组上调表达基因的代表性GO功能注释；B，来曲唑造模组上调表达基因的代表性KEGG富集分析；C，来曲唑造模组下调表达基因的代表性GO功能注释；D，来曲唑造模组下调表达基因的代表性 KEGG 富集分析。

Figure 3 Functional annotation and enrichment analysis of differentially expressed genes in mice after letrozole and high-fat diet modeling Note： A， Representative GO functional annotations of upregulated differentially expressed genes in the letrozole model group compared to the placebo control group； B， Representative KEGG enrichment analysis of upregulated differentially expressed genes in the letrozole model group compared to the placebo control group； C， Representative GO functional annotations of downregulated differentially expressed genes in the letrozole model group compared to the placebo control group； D， Representative KEGG enrichment analysis of downregulated differentially expressed genes in the letrozole model group compared to the placebo control group.