来曲唑缓释片皮下给药构建小鼠多囊卵巢综合征模型及其肝脏转录组学分析

许秋雨, 严国锋, 付丽, 范文华, 周晶, 朱莲, 仇淑雯, 张洁, 吴铃

A Mouse Model of Polycystic Ovary Syndrome Established Through Subcutaneous Administration of Letrozole Sustained-Release Pellets and Hepatic Transcriptome Analysis

XU Qiuyu, YAN Guofeng, FU Li, FAN Wenhua, ZHOU Jing, ZHU Lian, QIU Shuwen, ZHANG Jie, WU Ling

图 2 来曲唑和高脂饮食造模后小鼠肝脏组织中差异基因分析 注：A，来曲唑造模组 vs 安慰剂对照组的差异表达基因数量柱状图；B，来曲唑造模组 vs 安慰剂对照组的差异表达基因火山图。

Figure 2 Analysis of differentially expressed genes in liver of mice after letrozole and high-fat diet modeling Note：A， Bar chart of the number of differentially expressed genes between the letrozole model group and the placebo control group； B， Volcano plot of differentially expressed genes between the letrozole model group and the placebo control group.