利用辅助生殖技术挽救基因修饰小鼠的实例分析

王芊芊, 陶斯珏, 卫振, 金晖晖, 刘平, 汪洌

A Case Study of Using Assisted Reproductive Technology to Rescue Genetically Modified Mice with Reproductive Disorder Phenotypes

WANG Qianqian, TAO Sijue, WEI Zhen, JIN Huihui, LIU Ping, WANG Lie

表1 经体外受精-胚胎移植挽救的不育基因修饰小鼠的异形卵率、受精率及仔鼠出生率 (

\overset{ˉ}{x}

±s)

Table 1 Abnormal egg rate, fertility rate and birth rate of infertile genetically modified mice rescued by in vitro fertilization-embryo transfer

不育雄性小鼠月龄/月 Age of Infertile male mice/month	动物数量 n	异形卵率/% Abnormal egg rate/%	受精率/% Fertility rate/%	仔鼠出生率/% Birth rate/%
9	3	4.35±2.21	48.99±28.09	19.87±13.93
10	4	11.55±8.29	62.34±11.32	16.84±5.43
11	4	9.38±2.35	60.85±10.46	17.41±10.46
12	4	7.14±1.12	48.87±13.72	19.04±5.31
13	4	9.50±6.44	42.21±5.86	19.68±1.92
14	4	13.15±7.72	53.07±12.79	16.51±4.60
15	1	6.13	36.79	12.82
16	1	5.04	43.17	15.00
17	1	9.09	47.20	20.00
18	2	8.31±3.53	42.45±27.12	27.66±10.50