肝螺杆菌感染引起VDR-/-小鼠炎性肠病相关肠纤维化模型的建立及机制探讨
吴志浩1(), 曹舒扬2, 周正宇1()()
Establishment of an Intestinal Fibrosis Model Associated with Inflammatory Bowel Disease in VDR-/- Mice Induced by Helicobacter hepaticus Infection and Mechanism Exploration
WU Zhihao1(), CAO Shuyang2, ZHOU Zhengyu1()()

图1. H.hepaticus感染后各组小鼠的体重变化（A）、粪便含水量（B）和疾病活动指数评分（C）比较
注：VDR-/-对照组与其他3组比较，在感染10周后体重出现差异（*P<0.05，**P<0.01，n=5）。VDR-/-感染组小鼠粪便含水量和疾病活动指数评分均显著高于其他组（*P<0.05，**P<0.01，***P<0.001，****P<0.000 1，n=5）。

Figure 1. Body weight changes （A）， fecal water content （B）， and disease activity index score （C） of mice infected by H.hepaticus
Note： A significant disparity in body weight was observed after a 10-week infection period when comparing the VDR-/-control with the remaining three groups （*P<0.05， **P<0.01， n=5）. The fecal water content and disease activity index score in VDR-/-+H.h group mice were significantly higher compared to those in the other groups （*P<0.05， **P<0.01， ***P<0.001， ****P<0.000 1， n=5）.