基于UHPLC-QE-MS的高原鼠兔肾脏差异代谢物及低氧适应机制分析

何雨昕, 白振忠, 薛华, 郭子旭, 曹学锋

Analysis of Kidney Differential Metabolites and Hypoxia Adaptation Mechanism of Plateau Pikas Based on UHPLC-QE-MS

HE Yuxin, BAI Zhenzhong, XUE Hua, GUO Zixu, CAO Xuefeng

表2 不同海拔高原鼠兔的肾脏代谢物差异分子

Table 2 Differential molecules of kidney metabolites in plateau pikas at different altitudes

峰值 Peak	代谢物 Metabolites		MD组vs MY组 MD group vs MY group
峰值 Peak	中文名 Chinese name	英文名 English name	RT/s	VIP	P value	FC
4217	蟾蜍二烯羟酸内酯	Bufadienolide	302.521	2.841	0.046 1	216.417
3586	薯蓣皂苷配基	Diosgenin	375.853	2.790	0.000 0	23.644
2596	盐酸小檗碱	Berberine chloride	448.647	1.684	0.010 1	2.418
5668	顺丁烯二酰亚胺	Maleimide	157.759	2.051	0.003 3	2.275
6118	腺嘌呤	Adenine	128.009	1.992	0.002 6	1.355
4040	7,8-脱氢虾青素	7,8-Dehydroastaxanthin	304.975	2.124	0.007 8	13.719
4168	贝那普利酯	Benazeprilat	279.705	2.212	0.000 8	10.772
4196	胆固醇-3,7,12,25-呋喃-3-葡萄糖醛酸	Cholestane-3,7,12,25-tetrol-3-glucuronide	273.513	2.149	0.001 2	5.633
4221	7-乙氧基香豆素	7-Ethoxycoumarin	261.173	1.795	0.017 9	2.839
3212	1-硬脂酰甘油磷酸甘油	1-Stearoylglycerophosphoglycerol	412.530	1.586	0.025 1	2.103
5578	2-甲氧基对乙酰氨基酚硫酸盐	2-Methoxyacetaminophen sulfate	36.282	2.150	0.000 5	0.453
5294	黄嘌呤	Xanthosine	57.261	1.863	0.007 7	0.448
5476	四氢生物蝶呤	Tetrahydrobiopterin	42.319	1.632	0.011 0	0.425
2896	小穗苎麻素	Cryptopleurine	440.968	2.258	0.000 3	0.292
3198	坎二酸	Canbidiolic acid	413.844	2.004	0.012 7	0.284
5570	GDP-3,6-二脱氧-D-半乳糖	GDP-3,6-dideoxy-D-galactose	36.317	1.735	0.001 6	0.197
5501	棉酚	Gossypol	41.544	1.725	0.019 3	0.160
4549	4-香豆素基莽草酸酯	4-Coumaroylshikimate	179.435	2.266	0.009 7	0.103
4596	紫丁香苷	Syringin	169.451	2.374	0.010 3	0.050
5805	5-O-甲基-间氨基-肌醇	5-O-Methyl-myo-inositol	33.358	2.543	0.000 5	0.026
5001	癸二酸	Sebacic acid	135.122	2.295	0.046 3	0.077
4671	萨马素A	Samaderin A	163.209	1.535	0.037 8	0.217
4717	3-脱氢酶	3-Dehydrogenase	157.505	2.158	0.000 9	0.170
4514	硫烯草丹	Sulfallate	185.215	1.844	0.049 0	0.190
5688	双甲苯苄醇	Bitolterol	35.519	1.568	0.001 1	0.271
5523	烟碱	Nicotiamine	169.858	2.201	0.000 1	0.454
7265	吡达隆	Pyridarone	29.322	1.490	0.019 5	0.401
3058	高肌肽	Homocarnosine	412.238	1.966	0.006 3	0.390
3410	阿非迪霉素	Aphidicolin	388.298	2.133	0.005 0	0.205
3101	松香酸盐	Abietate	408.903	2.373	0.033 4	0.088
4573	秦皮苷	Fraxin	174.802	1.098	0.034 3	0.085
3554	高多环内酯	Homodolicholide	380.038	1.667	0.004 0	0.234
3984	法尼基半胱氨酸	Farnesylcysteine	328.343	2.148	0.015 9	0.224
59	泛酸	Pantothenic acid	157.754	2.460	0.000 1	0.480
6640	1-甲基腺苷	1-Methyladenosine	44.286	2.135	0.003 3	0.482
5674	L-二氢脱壳素	L-Dihydroanticapsin	157.754	2.510	0.000 1	0.463
3695	十八碳四烯酸	Stearidonic acid	359.953	2.698	0.003 7	0.103
4631	6-脱氧巴西红厚壳素	6-Deoxyjacareubin	237.103	2.310	0.011 0	0.096
5940	异戊烯焦磷酸	Isopentenyl diphosphate	142.170	2.771	0.038 3	0.004
6407	环氧化物青蒿琥酯	Artomunoxanthentrione epoxide	27.729	2.401	0.000 0	0.249
5768	苄基青霉酸	Benzylpenicilloic acid	151.870	2.655	0.025 4	0.034
302	异亮氨酸	Isoleucine	71.954	1.669	0.045 9	0.698
6496	L-缬氨酸	L-Valine	55.803	1.684	0.018 2	0.637
4165	鼠尾草酚	Carnosol	279.762	2.070	0.003 8	31.391
41	花生四烯酸	Arachidonic acid	466.526	1.614	0.010 5	0.695
5711	组胺	Histamine	35.217	1.740	0.042 9	0.537