基于UHPLC-QE-MS的高原鼠兔肾脏差异代谢物及低氧适应机制分析
何雨昕1(), 白振忠1,2, 薛华1, 郭子旭1, 曹学锋1,2()()
Analysis of Kidney Differential Metabolites and Hypoxia Adaptation Mechanism of Plateau Pikas Based on UHPLC-QE-MS
HE Yuxin1(), BAI Zhenzhong1,2, XUE Hua1, GUO Zixu1, CAO Xuefeng1,2()()

图2. 不同海拔高原鼠兔的肾脏差异代谢物相关性及其相关通路
注：A为相关性分析热力图（Corr为变量相关系数）；B为火山图（VIP为变量投影重要度；FC为倍数变化，即两组代谢物定量的比值；P 值反映两组差异代谢物的显著性概率）；C为通路识别气泡图；D为通路识别矩形图（Gm即甘油磷脂代谢；Pm即嘌呤代谢）。

Figure 2. Correlation of kidney differential metabolites and related pathways in plateau pikas at different altitudes
Note：A is correlation analysis heat map （Corr， correlation coefficients of variables）； B is the volcano plot （VIP， variable importance in projection； FC， fold change， the quantitative ratio of two groups of experimental substances； P value， probability of significance of different metabolites between the two groups）； C is the pathway recognition bubble chart； D is the path identification rectangular graph （Gm， glycerophospholipid metabolism； Pm， purine metabolism）.