实验动物与比较医学 ›› 2019, Vol. 39 ›› Issue (3): 236-238.DOI: 10.3969/j.issn.1674-5817.2019.03.011

• 经验交流 • 上一篇    下一篇

一例食蟹猴肠套叠诊断与治疗

李良顺1, 潘世友2, 支元芳3, 白帅州3, 孙建华3, 宫丽崑3, 任进3   

  1. 1.上海交通大学农业与生物学院, 上海 201203;
    2.上海喜乐缘宠物医院, 上海 201299;
    3.中国科学院上海药物研究所, 上海 201203
  • 收稿日期:2018-08-08 出版日期:2019-06-25 发布日期:2021-01-29
  • 作者简介:李良顺(1984-),男,兽医,主要从事实验动物学研究。E-mail:lsli@cdser.simm.ac.cn

Diagnosis and Treatment for Intussusceptions in One Case of Cynomolgus Monkey

LI Liang-shun1, PAN Shi-you2, ZHI Yuan-fang3, BAI shuai-zhou3, SUN Jian-hua3, GONG Li-kun3, REN Jin3   

  1. 1. Shanghai Jiao Tong University School of Agriculture and Biology, Shanghai 201203, China;
    2. Shanghai Xi Le Yuan Pet Hospital, Shanghai 201299, China;
    3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • Received:2018-08-08 Online:2019-06-25 Published:2021-01-29

摘要: 长期毒性试验中,一只食蟹猴发生肠套叠,结合临床症状、血液生化指标检测、触诊和B超等方法确诊,采用体外按摩法复位套叠肠段,复位后采取补充能量、解痉、限食等护理措施,动物恢复良好,毒性试验如期进行。结果表明,触诊和B超相结合的方法,可准确诊断早期肠套叠; 采用体外按摩法可有效治疗早期肠套叠,且不影响长期毒性试验开展。

关键词: 肠套叠, 食蟹猴, 非手术治疗, B超诊断

Abstract: Intussusception occurred in a cynomolgus during a repeat dose toxicity study. Intussusception of cynomolgus was diagnosed by using the methods of clinical observation, hematology and plasma chemistry analysis, palpation and bultrasonic. Reset the intussusceptions by manually in vitro. The actions of supplying energy and antispasmodic drug and dietary restriction were performed for nursing. The animal recovered very well, and the toxicity study proceeded as scheduled. The results indicated that the inchoate intussusception could be correctly diagnosed by using the methods of palpation and bultrasonic; and the inchoate intussusceptions could be effective treated by manually in vitro, and the repeat dose toxicity study wouldn’t be influenced.

Key words: Intussusception, Cynomolgus monkey, Non-surgical therapy, Bultrasonic diagnostic

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